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KMID : 0857020060210010333
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Kosin Medical Journal
2006 Volume.21 No. 1 p.333 ~ p.337
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The significance of pS2 gene alteration in the early gastric cancer
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Chang Hee-Kyung
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Abstract
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Background and Purpose : The expression of pS2 gene in normal human tissue is restricted to the stomach. But its role in tumor development is not elucidated yet. The purpose of this study is to evaluate the functional role of pS2 protein in early gastric carcinomas(EGC), by investigating prevalence of the gene and analysing its expression with histologic types and differentiation.
Material and Method : The formalin-fixed and paraffin-embedded tissue obtained from 100 patients with EGC who underwent gastrectomy by using immunohistochemistry.
Results : In the non-neoplastic tissue adjacent to the tumor, the immunoreactivity for pS2 was observed in the cytoplasms of superficial and foverolar epithelium and a few chief cells, while intestinalmetaplastic epithelium showed negative immunoreactivity. The neoplastic tissue revealed cytoplasmic positive staining of tumor cells. The overall immunoreactivity for pS2 in 100 EGC cases is 56%. The expression of pS2 was significantly higher in diffuse type(65.9%) than interstinal type(48.2%)(p<0.05) and also higher than in poorly-differentiated type(62.1%) than in well-differentiated type(47.6%)(p<0.05). The expression rates of tumors invading to mucosa was 53.1% (17/32) and tumors invading to submucosa was 46.9%(15/32).
Conclusion: These results mean that the expression of pS2 is correlated to the histologic type and grading, while is not related to the depth of tumor invasion. And it is indicated that pS2 protein has a yet undescribed role in gastric foveolar epithelium and pS2 gene expression may be more important role in diffuse type cancer than in intestinal type cancer of stomach
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KEYWORD
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pS2, Early gastric cancer, Lauren classification
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